Protein Details: Potassium voltage-gated channel subfamily D member 1
Protein ID
ICDB_Pro_1585
Protein Name
Potassium voltage-gated channel subfamily D member 1
Gene Name
KCND1
Organism
Homo sapiens (Human)
Length
647 amino acids
AlphaFoldDB
AF-Q9NSA2-F1-model_v4.pdb
Function
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits
Sequence
MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL
PDB Structures
Ligand Binding
Binding Site
104;131;132
Disease
Location
Widely expressed. Highly expressed in brain; in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.
DOI ID
10.1006/geno.2000.6117; 10.1038/ng1285; 10.1038/nature03440; 10.1101/gr.2596504; 10.1529/biophysj.104.042358
RefSeq
NP_004970.3 [Q9NSA2-1]; XP_011542212.1